Expresión de búsqueda:
KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
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DeCS
Descriptor
Inglés
:
Kelch-Like ECH-Associated Protein 1
Descriptor
Español
:
Proteína 1 Asociada A ECH Tipo Kelch
Descriptor
Portugués
:
Proteína 1 Associada a ECH Semelhante a Kelch
Sinónimos
Inglés
:
KEAP-1 Protein
KEAP1 Protein
KEAP 1 Protein
Kelch Like ECH Associated Protein 1
Categoría:
D12.644.360.024.306
D12.776.157.057.067
D12.776.476.024.387
Definición
Inglés
:
An adaptor protein characterized by an N-terminal
BTB-POZ DOMAIN
and six KELCH REPEATS that functions as a substrate for the E3
UBIQUITIN
LIGASE complex. It negatively-regulates
NF-E2-RELATED FACTOR 2
by targeting it for
ubiquitination
and degradation by the PROTEASOME. It also represses genes regulated by
ANTIOXIDANT RESPONSE ELEMENTS.
Nota Histórica
Inglés
:
2017
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
56536
Identificador Único:
D000072019
Ocurrencia en la BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS